An atypical mitogen-activated protein kinase (MAPK) homologue expressed in gametocytes of the human malaria parasite Plasmodium falciparum. Identification of a MAPK signature.

@article{Dorin1999AnAM,
  title={An atypical mitogen-activated protein kinase (MAPK) homologue expressed in gametocytes of the human malaria parasite Plasmodium falciparum. Identification of a MAPK signature.},
  author={Dominique Dorin and Pietro Alano and Ir{\'e}ne Boccaccio and Liliane Cic{\'e}ron and Ronan Sulpice and Daniel Parzy and Caroline Doerig},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 42},
  pages={29912-20}
}
The cDNA encoding Pfmap-2, an enzyme of the human malaria parasite Plasmodium falciparum, was cloned, sequenced, and expressed in Escherichia coli. The open reading frame carried by the Pfmap-2 cDNA encodes a 508-amino acid polypeptide of 59.2 kDa with maximal homology to mitogen-activated protein kinases (MAPKs) from various organisms. The purified recombinant enzyme displayed functional characteristics of MAPKs such as (i) ability to undergo autophosphorylation, (ii) ability to phosphorylate… CONTINUE READING

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