An attenuated variant of eastern encephalitis virus: Biological properties and protection induced in mice


Wild type Eastern equine encephalitis virus (E) was compared with a mutant (Em) derived from it. The latter was tested as an attenuated vaccine in mice. They differed in the following properties: Em formed smaller plaques on chick embryo (CE) cell monolayers and, unlike E, did not plaque on mouse embryo (ME) monolayers. Further, Em had a longer latent… (More)
DOI: 10.1007/BF01320552

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