An atomic model for actin binding by the CH domains and spectrin-repeat modules of utrophin and dystrophin.

@article{SutherlandSmith2003AnAM,
  title={An atomic model for actin binding by the CH domains and spectrin-repeat modules of utrophin and dystrophin.},
  author={Andrew J. Sutherland-Smith and Carolyn A Moores and Fiona L M Norwood and Victoria Hatch and Roger Craig and John Kendrick-Jones and William Lehman},
  journal={Journal of molecular biology},
  year={2003},
  volume={329 1},
  pages={15-33}
}
Utrophin and dystrophin link cytoskeletal F-actin filaments to the plasmalemma. Genetic strategies to replace defective dystrophin with utrophin in individuals with muscular dystrophy requires full characterization of these proteins. Both contain homologous N-terminal actin-binding motifs composed of a pair of calponin-homology (CH) domains (CH1 and CH2) that are connected by spectrin-repeat modules to C-terminal membrane-binding sequences. Here, electron microscopy and 3D reconstruction of F… CONTINUE READING

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