An association study of the codon 72 polymorphism in the pro-apoptotic gene p53 and Alzheimer's disease.

@article{Rosenmann2003AnAS,
  title={An association study of the codon 72 polymorphism in the pro-apoptotic gene p53 and Alzheimer's disease.},
  author={Hanna Rosenmann and Zeev Meiner and Esther Kahana and Zoja Aladjem and Gideon Friedman and Arie Ben-Yehuda and Tal Grenader and Eli Wertman and Oded Abramsky},
  journal={Neuroscience letters},
  year={2003},
  volume={340 1},
  pages={29-32}
}
Recent studies have demonstrated that p53-associated apoptosis is involved in the pathogenesis of Alzheimer's disease (AD). We performed a case-control association study between sporadic AD and the common proline/arginine polymorphism at codon 72 in the pro-apoptotic gene p53, in 109 sporadic AD patients and in 111 controls. This polymorphism has been intensively investigated for association with cancer, but so far not with AD and neurodegeneration. We found no association between this locus… CONTINUE READING

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