An association between low maternal serum alpha-fetoprotein and fetal chromosomal abnormalities.

@article{Merkatz1984AnAB,
  title={An association between low maternal serum alpha-fetoprotein and fetal chromosomal abnormalities.},
  author={Irwin R. Merkatz and HaroldM. Nitowsky and J. N. Macri and Wendell E. Johnson},
  journal={American journal of obstetrics and gynecology},
  year={1984},
  volume={148 7},
  pages={
          886-94
        }
}
An index case of "undetectable" maternal serum alpha-fetoprotein at 16 weeks in the first pregnancy of a 28-year-old woman was associated with birth of an infant with trisomy 18. This fortuitous finding stimulated a retrospective study of prenatally diagnosed chromosomal abnormalities. From among a series of 3,862 genetic amniocenteses, 32 cases of fetal autosomal trisomy were diagnosed for which corresponding maternal serum and amniotic fluid alpha-fetoprotein data could be retrieved. From a… CONTINUE READING

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