An association between a Bc1I restriction fragment length polymorphism of the glucocorticoid receptor locus and hyperinsulinaemia in obese women.

@article{Weaver1992AnAB,
  title={An association between a Bc1I restriction fragment length polymorphism of the glucocorticoid receptor locus and hyperinsulinaemia in obese women.},
  author={Jolanta U. Weaver and Graham A. Hitman and Peter G. Kopelman},
  journal={Journal of molecular endocrinology},
  year={1992},
  volume={9 3},
  pages={295-300}
}
Obesity is likely to be a multifactorial disease with an important genetic component. Animal models of genetic and experimentally induced obesity suggest that glucocorticoid receptor (GR) activity plays a role in the aetiology and maintenance of the obese state. Glucocorticoid activity appears to be essential for the development of hyperinsulinaemia and subsequent fat deposition. In humans, glucocorticoid excess is associated with central fat distribution. We have therefore investigated the… CONTINUE READING

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