An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients.

@article{Rha2007AnAB,
  title={An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients.},
  author={Sun Young Rha and Hei-Cheul Jeung and Yeon ho Choi and Woo Ick Yang and Jin Ho Yoo and Byung Soo Kim and Jae Kyung Roh and Hyun Cheol Chung},
  journal={The oncologist},
  year={2007},
  volume={12 6},
  pages={622-30}
}
PURPOSE We examined the pattern of single-nucleotide polymorphisms (SNPs) of gemcitabine metabolism-related and target genes in breast cancer patients and evaluated their association with drug response or toxicity. PATIENTS AND METHODS SNPs in deoxycytidine kinase (dCK), deoxycytidine monophosphate deaminase (DCTD), and ribonucleotide reductase M1 polypeptide (RRM1) were analyzed with genomic DNA of 10 breast cancer cell lines, 74 peripheral blood mononuclear cell (PBMC) samples from advanced… CONTINUE READING

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