An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.

@article{Edwards2009AnAA,
  title={An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.},
  author={Todd E Edwards and Margaret A. Pericak-Vance and Johnny R. Gilbert and Jonathan L. Haines and Eden R. Martin and Marylyn DeRiggi Ritchie},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2009},
  volume={150B 5},
  pages={
          721-35
        }
}
  • Todd E Edwards, Margaret A. Pericak-Vance, +3 authors Marylyn DeRiggi Ritchie
  • Published in
    American journal of medical…
    2009
  • Medicine, Biology
  • Alzheimer's disease (AD) is the most common form of progressive dementia in the elderly. It is a neurodegenerative disorder characterized by the neuropathologic findings of neurofibrillary tangles and amyloid plaques that accumulate in vulnerable brain regions. AD etiology has been studied by many groups, but since the discovery of the APOE epsilon4 allele, no further genes have been mapped conclusively to late-onset AD (LOAD). In this study, we examined genetic association with LOAD… CONTINUE READING

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