An assessment of the validity of densitometric measures of striatal tyrosine hydroxylase-positive fibers: relationship to apomorphine-induced rotations in 6-hydroxydopamine lesioned rats.

@article{Burke1990AnAO,
  title={An assessment of the validity of densitometric measures of striatal tyrosine hydroxylase-positive fibers: relationship to apomorphine-induced rotations in 6-hydroxydopamine lesioned rats.},
  author={Robert E Burke and Jean Lud Cadet and Joan Kent and A L Karanas and Vernice R. Jackson-Lewis},
  journal={Journal of neuroscience methods},
  year={1990},
  volume={35 1},
  pages={63-73}
}
The power of immunohistochemical staining as a tool for the study of the neurochemical anatomy of the brain would be greatly enhanced if quantitative measures of staining were to be developed. We have here assessed the reliability and validity of two population measures of extent of fiber innervation: percent area occupied by staining, and average optical density (AOD) of staining. We have evaluated these measures for tyrosine hydroxylase-positive staining of the striatum in relation to… CONTINUE READING