An assessment of the efficiency of PrPsc detection in rectal mucosa and third-eyelid biopsies from animals infected with scrapie.

@article{Monlen2011AnAO,
  title={An assessment of the efficiency of PrPsc detection in rectal mucosa and third-eyelid biopsies from animals infected with scrapie.},
  author={Eva Monle{\'o}n and Ma Carmen Garza and Roc{\'i}o Sarasa and Javier {\'A}lvarez-Rodr{\'i}guez and R. G. Bolea and Marta Monz{\'o}n and Michele A. Vargas and Juan Jos{\'e} Badiola and Cristina Ac{\'i}n},
  journal={Veterinary microbiology},
  year={2011},
  volume={147 3-4},
  pages={237-43}
}
In classical scrapie, detection of PrPsc on lymphoreticular system is used for the in vivo and post mortem diagnosis of the disease. However, the sensitivity of this methodology is not well characterised because the magnitude and duration of lymphoid tissue involvement can vary considerably. The aim of the present study was to evaluate the efficiency of detecting PrPsc in rectal mucosa and third-eyelid biopsies. A total of 474 genetically susceptible sheep and 24 goats from three scrapie… CONTINUE READING
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