An assembly of proteins and lipid domains regulates transport of phosphatidylserine to phosphatidylserine decarboxylase 2 in Saccharomyces cerevisiae.

@article{Riekhof2014AnAO,
  title={An assembly of proteins and lipid domains regulates transport of phosphatidylserine to phosphatidylserine decarboxylase 2 in Saccharomyces cerevisiae.},
  author={Wayne R. Riekhof and W I Wu and Jennifer L. Jones and Mrinalini P. Nikrad and Mallory M. Chan and Christopher J. R. Loewen and Dennis R. Voelker},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 9},
  pages={5809-19}
}
Saccharomyces cerevisiae uses multiple biosynthetic pathways for the synthesis of phosphatidylethanolamine. One route involves the synthesis of phosphatidylserine (PtdSer) in the endoplasmic reticulum (ER), the transport of this lipid to endosomes, and decarboxylation by PtdSer decarboxylase 2 (Psd2p) to produce phosphatidylethanolamine. Several proteins and protein motifs are known to be required for PtdSer transport to occur, namely the Sec14p homolog PstB2p/Pdr17p; a PtdIns 4-kinase, Stt4p… CONTINUE READING
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