An assay for uracil in human DNA at baseline: effect of marginal vitamin B6 deficiency.

@article{Mashiyama2008AnAF,
  title={An assay for uracil in human DNA at baseline: effect of marginal vitamin B6 deficiency.},
  author={Susan T. Mashiyama and Christine M Hansen and Esther Roitman and Stella Sarmiento and James E. Leklem and Terry D. Shultz and Bruce N. Ames},
  journal={Analytical biochemistry},
  year={2008},
  volume={372 1},
  pages={21-31}
}
Improvements are made to our gas-chromatography-mass-spectrometry-based assay for quantifying low levels of DNA-uracil. Folate deficiency leads to increased deoxyuridine monophosphate/thymidylate (dUMP/dTMP) ratios and uracil misincorporation into DNA, which may increase cancer risk. Vitamin B6 (B6) deficiency might also result in increased DNA-uracil because B6 is a cofactor for serine hydroxymethyltransferase, which catalyzes the methylation of tetrahydrofolate (THF) to methylene-THF, the… CONTINUE READING

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