An assay for superoxide dismutase activity in mammalian tissue homogenates.

  title={An assay for superoxide dismutase activity in mammalian tissue homogenates.},
  author={Douglas R. Spitz and Larry W. Oberley},
  journal={Analytical biochemistry},
  volume={179 1},
During the course of measuring superoxide dismutase (SOD) activity in rat breast tissue, interferences in the nitroblue tetrazolium (NBT) and cytochrome c assay systems were noted. These interferences inhibit accurate measurement of SOD activity in breast tissues, necessitating the development of a new NBT-based assay that includes compounds capable of inhibiting tissue specific interferences. The most effective compounds were metal chelators that were also electron transport chain inhibitors… CONTINUE READING
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