An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis

@article{Kizawa2005AnAA,
  title={An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis},
  author={Hideki Kizawa and Ikuyo Kou and Aritoshi Iida and Akihiro Sudo and Yoshinari Miyamoto and Akira Fukuda and Akihiko Mabuchi and Akihiro Kotani and Akira Kawakami and Seizo Yamamoto and Atsumasa Uchida and Kozo Nakamura and Kohei Notoya and Yusuke Nakamura and Shiro Ikegawa},
  journal={Nature Genetics},
  year={2005},
  volume={37},
  pages={138-144}
}
Osteoarthritis is the most common form of human arthritis. We investigated the potential role of asporin, an extracellular matrix component expressed abundantly in the articular cartilage of individuals with osteoarthritis, in the pathogenesis of osteoarthritis. Here we report a significant association between a polymorphism in the aspartic acid (D) repeat of the gene encoding asporin (ASPN) and osteoarthritis. In two independent populations of individuals with knee osteoarthritis, the D14… CONTINUE READING
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