An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture.

@article{Lee2007AnAL,
  title={An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture.},
  author={Philip S. Lee and Paul J Hung and Luke P. Lee},
  journal={Biotechnology and bioengineering},
  year={2007},
  volume={97 5},
  pages={1340-6}
}
Primary hepatocytes represent a physiologically relevant model for drug toxicity screening. Here, we created a biologically inspired artificial liver sinusoid with a microfluidic endothelial-like barrier having mass transport properties similar to the liver acinus. This unit consisted of a cord of hepatocytes (50 x 30 x 500 microm) fed by diffusion of nutrients across the microfluidic endothelial-like barrier from a convective transport vessel (10 nL/min). This configuration sustained rat and… CONTINUE READING

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