An artificial gene for human porphobilinogen synthase allows comparison of an allelic variation implicated in susceptibility to lead poisoning.

@article{Jaffe2000AnAG,
  title={An artificial gene for human porphobilinogen synthase allows comparison of an allelic variation implicated in susceptibility to lead poisoning.},
  author={Eileen K Jaffe and Michael V.. Volin and C R Bronson-Mullins and Roland L. Dunbrack and Jukka Kervinen and Jacob Martins and James F. Quinlan and Matthew Howard Sazinsky and E M Steinhouse and Anthony T. Yeung},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 4},
  pages={
          2619-26
        }
}
Porphobilinogen synthase (PBGS) is an ancient enzyme essential to tetrapyrrole biosynthesis (e.g. heme, chlorophyll, and vitamin B(12)). Two common alleles encoding human PBGS, K59 and N59, have been correlated with differential susceptibility of humans to lead poisoning. However, a model for human PBGS based on homologous crystal structures shows the location of the allelic variation to be distant from the active site with its two Zn(II). Previous microbial expression systems for human PBGS… CONTINUE READING

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