An architectural perspective on signaling by the pre-, alphabeta and gammadelta T cell receptors.

@article{Hayes2003AnAP,
  title={An architectural perspective on signaling by the pre-, alphabeta and gammadelta T cell receptors.},
  author={Sandra M. Hayes and Elizabeth W. Shores and Paul E Love},
  journal={Immunological reviews},
  year={2003},
  volume={191},
  pages={
          28-37
        }
}
The T cell antigen receptor (TCR) is a multimeric complex composed of an antigen-binding clonotypic heterodimer and a signal transducing complex consisting of the CD3 dimers (CD3gammaepsilon and CD3deltaepsilon) and a TCR-zeta homodimer. In all jawed vertebrates there are two T cell lineages, alphabeta and gammadelta, distinguished by the clonotypic subunits contained within their TCRs (TCR-alpha and -beta or TCR-gamma and -delta, respectively). A third receptor complex, the preTCR, is only… CONTINUE READING

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