An arachidonate metabolite is involved in the conversion from alpha 1- to beta-adrenergic glycogenolysis in isolated rat liver cells.

@article{Ishac1986AnAM,
  title={An arachidonate metabolite is involved in the conversion from alpha 1- to beta-adrenergic glycogenolysis in isolated rat liver cells.},
  author={Edward J N Ishac and George Kunos},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1986},
  volume={83 1},
  pages={53-7}
}
In vitro incubation of isolated rat liver cells in a serum-free buffer leads to the suppression of the glycogenolytic effect of phenylephrine and the simultaneous emergence of a glycogenolytic response to isoproterenol within 4 hr. This time-dependent conversion of the adrenergic receptor response from alpha 1 to beta type is prevented by the presence in the incubation medium of 0.5% fatty-acid-free, but not regular, bovine serum albumin. A 20-min exposure of freshly isolated liver cells to… CONTINUE READING

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…