An aqueous channel for filamentous phage export.

@article{Marciano1999AnAC,
  title={An aqueous channel for filamentous phage export.},
  author={Dominic Marciano and Marjorie Russel and Sharotka M. Simon},
  journal={Science},
  year={1999},
  volume={284 5419},
  pages={1516-9}
}
Filamentous phage f1 exits its Escherichia coli host without killing the bacterial cell. It has been proposed that f1 is secreted through the outer membrane via a phage-encoded channel protein, pIV. A functional pIV mutant was isolated that allowed E. coli to grow on large maltodextrins and rendered E. coli sensitive to large hydrophilic antibiotics that normally do not penetrate the outer membrane. In planar lipid bilayers, both mutant and wild-type pIV formed highly conductive channels with… CONTINUE READING

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