An approach to the immunophenotypic features of circulating CD4+NKG2D+ T cells in invasive cervical carcinoma

  title={An approach to the immunophenotypic features of circulating CD4+NKG2D+ T cells in invasive cervical carcinoma},
  author={M. Garc{\'i}a-Chagoll{\'a}n and L. Jave-Su{\'a}rez and J. Haramati and M. Bueno-Topete and A. Aguilar-Lemarroy and C. Estrada-Ch{\'a}vez and B. E. Bastidas-Ram{\'i}rez and A. Pereira-Su{\'a}rez and S. del Toro-Arreola},
  journal={Journal of Biomedical Science},
  • M. García-Chagollán, L. Jave-Suárez, +6 authors S. del Toro-Arreola
  • Published 2015
  • Medicine, Biology
  • Journal of Biomedical Science
  • BackgroundNKG2D, an activating immunoreceptor, is primarily restricted to NK cells and CD8+ T cells. The existence of an atypical cytotoxic CD4+NKG2D+ T cell population has also been found in patients with autoimmune dysfunctions. Nonetheless, contradictory evidence has categorized this population with a regulatory rather than cytotoxic role in other situations. These confounding data have led to the proposal that two distinct CD4+NKG2D+ T cell subsets might exist. The immune response elicited… CONTINUE READING
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