Corpus ID: 45851321

An approach to the design and synthesis of mercaptoimidazole derivatives containing oxidized sulfur based on electron affinity sensitization.

@article{Inayama1981AnAT,
  title={An approach to the design and synthesis of mercaptoimidazole derivatives containing oxidized sulfur based on electron affinity sensitization.},
  author={S. Inayama and Hitoshi Hori and T Ohsaka and T. Mori and Chieko Shibata},
  journal={Gan},
  year={1981},
  volume={72 1},
  pages={
          156-9
        }
}
New mercaptoimidazole derivatives containing oxidized sulfur were designed and synthesized for screening with hypoxic radioresistant cells in place of nitroimidazoles, which are well-known radiosensitizing agents. The electron affinities of various mercaptoimidazole derivatives such as the sulfoxide (4) and sulfone (5) were estimated on the basis of the lowest unoccupied molecular orbital (LUMO) by using the CDNO/2 method. Compounds (4) and (5) thus designed were synthesized from the sulfide (3… Expand
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