An approach to multi-copy search in molecular replacement.

  title={An approach to multi-copy search in molecular replacement.},
  author={Alexei A. Vagin and Alexei Teplyakov},
  journal={Acta crystallographica. Section D, Biological crystallography},
  volume={56 Pt 12},
The molecular-replacement method has been extended to a simultaneous search for multiple copies of the macromolecule in the unit cell. The central point of this approach is the construction of a multi-copy search model from the properly oriented monomers using a special translation function. The multi-copy search method has been implemented in the program MOLREP and successfully tested using experimental data. 
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