An approach to evaluating thrombolytic therapy in acute myocardial infarction. The 'unsatisfactory outcome' end point.

@article{Braunwald1992AnAT,
  title={An approach to evaluating thrombolytic therapy in acute myocardial infarction. The 'unsatisfactory outcome' end point.},
  author={Eugene Braunwald and Christopher Paul Cannon and Carolyn H. McCabe},
  journal={Circulation},
  year={1992},
  volume={86 2},
  pages={683-7}
}
T he primary goal of thrombolytic therapy in acute myocardial infarction (AMI) is the early restoration of perfusion and maintenance of viability and function of myocardium that would otherwise undergo necrosis consequent to thrombotic coronary artery occlusion. The salvage achieved by thrombolysis ranges from a minute amount of myocardium of little functional significance to a large mass of heart muscle the necrosis of which could cause death, with an intermediate quantity in most patients… CONTINUE READING
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