An approach to engineer paracetamol crystals by antisolvent crystallization technique in presence of various additives for direct compression.

@article{Kaialy2014AnAT,
  title={An approach to engineer paracetamol crystals by antisolvent crystallization technique in presence of various additives for direct compression.},
  author={Waseem Kaialy and Hassan Larhrib and Brian Chikwanha and Saeed Shojaee and Ali Nokhodchi},
  journal={International journal of pharmaceutics},
  year={2014},
  volume={464 1-2},
  pages={
          53-64
        }
}
Paracetamol is a popular over-the-counter analgesic and a challenging model drug due to its poor technological and biopharmaceutical properties such as flowability, compressibility, compactibility and wettability. This work was aimed to alter the crystal habit of paracetamol from elongated to polyhedral-angular via particle engineering whilst maintaining the stable polymorphic form (form I: monoclinic form). The engineered paracetamol crystals obtained in the present investigation showed better… CONTINUE READING
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Effects of operating conditions on agglomeration and habit of paracetamol crystals in anti - solvent crystallization

  • R. Tan, P. Chow
  • J . Cryst . Growth
  • 2005

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