An apparent paradox: attenuation of phenylephrine-mediated calcium mobilization and hyperreactivity to phenylephrine in contralateral carotid after balloon injury.

@article{Pereira2010AnAP,
  title={An apparent paradox: attenuation of phenylephrine-mediated calcium mobilization and hyperreactivity to phenylephrine in contralateral carotid after balloon injury.},
  author={Aline de Castro Pereira and Vania Claudia Olivon and Ana Maria de Oliveira},
  journal={Journal of cardiovascular pharmacology},
  year={2010},
  volume={56 2},
  pages={162-70}
}
Balloon catheter injury promotes hyperreactivity to phenylephrine (Phe) in the contralateral carotid. Phe-induced contraction involves calcium mobilization, a process that may be sensitive to reactive oxygen species. In this study, we investigated whether increased reactivity to Phe in the contralateral carotid is due to alterations in calcium mobilization by Phe and reactive oxygen species signaling. Concentration-response curves to Phe were obtained in control and contralateral arteries 4… CONTINUE READING
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