An apoptosis-differentiation program in human polymorphonuclear leukocytes facilitates resolution of inflammation.

@article{Kobayashi2003AnAP,
  title={An apoptosis-differentiation program in human polymorphonuclear leukocytes facilitates resolution of inflammation.},
  author={Scott D. Kobayashi and Jovanka M. Voyich and Greg A Somerville and Kevin R. Braughton and Harry L Malech and James M. Musser and Frank R Deleo},
  journal={Journal of leukocyte biology},
  year={2003},
  volume={73 2},
  pages={315-22}
}
Human polymorphonuclear leukocytes (PMNs) are an essential part of innate immunity and contribute significantly to inflammation. Although much is understood about the inflammatory response, the molecular basis for termination of inflammation in humans is largely undefined. We used human oligonucleotide microarrays to identify genes differentially regulated during the onset of apoptosis occurring after PMN phagocytosis. Genes encoding proteins that regulate cell metabolism and vesicle… CONTINUE READING
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