An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton.

@article{Short1998AnAP,
  title={An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton.},
  author={Douglas B. Short and Kevin W. Trotter and David Reczek and Silvia M. Kreda and Anthony Bretscher and Richard C. Boucher and M Jackson Stutts and Sharon L. Milgram},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 31},
  pages={19797-801}
}
The function of the cystic fibrosis transmembrane conductance regulator (CFTR) as a Cl- channel in the apical membrane of epithelial cells is extensively documented. However, less is known about the molecular determinants of CFTR residence in the apical membrane, basal regulation of its Cl- channel activity, and its reported effects on the function of other transporters. These aspects of CFTR function likely require specific interactions between CFTR and unknown proteins in the apical… CONTINUE READING
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