An antiviral peptide targets a coiled-coil domain of the human T-cell leukemia virus envelope glycoprotein.

@article{Pin2003AnAP,
  title={An antiviral peptide targets a coiled-coil domain of the human T-cell leukemia virus envelope glycoprotein.},
  author={Josefina D. Pi{\~n}{\'o}n and Sharon M Kelly and Nicholas S. C. Price and Jack Urquhart Flanagan and David W. Brighty},
  journal={Journal of virology},
  year={2003},
  volume={77 5},
  pages={3281-90}
}
Retrovirus entry into cells is mediated by the viral envelope glycoproteins which, through a cascade of conformational changes, orchestrate fusion of the viral and cellular membranes. In the absence of membrane fusion, viral entry into the host cell cannot occur. For human T-cell leukemia virus type 1 (HTLV-1), synthetic peptides that mimic a carboxy-terminal region of the transmembrane glycoprotein (TM) ectodomain are potent inhibitors of membrane fusion and virus entry. Here, we demonstrate… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Similar Papers

Loading similar papers…