An antimutator deoxyribonucleic acid polymerase. II. In vitro and in vivo studies of its temperature sensitivity.

@article{Lo1976AnAD,
  title={An antimutator deoxyribonucleic acid polymerase. II. In vitro and in vivo studies of its temperature sensitivity.},
  author={K. W. Y. Lo and Maurice J. Bessman},
  journal={The Journal of biological chemistry},
  year={1976},
  volume={251 8},
  pages={2480-6}
}
Upon infection of Escherichia coli with the temperature-sensitive bacteriophage T4 mutant, L141, at 43 degrees, DNA polymerase activity is induced, yet there is a marked decrease in DNA synthesis. Temperature shift experiments of infected cultures show dramatic changes in the rate of DNA synthesis, while the polymerase activity in extracts remains constant… CONTINUE READING