An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome

@inproceedings{Florin2017AnAP,
  title={An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome},
  author={Tanja Florin and Cristina Maracci and Michael Graf and Prajwal Karki and Dorota Klepacki and Otto Berninghausen and Roland Beckmann and Nora V{\'a}zquez-Laslop and Daniel N. Wilson and Marina V. Rodnina and Alexander S Mankin},
  booktitle={Nature Structural &Molecular Biology},
  year={2017}
}
Many antibiotics stop bacterial growth by inhibiting different steps of protein synthesis. However, no specific inhibitors of translation termination are known. Proline-rich antimicrobial peptides, a component of the antibacterial defense system of multicellular organisms, interfere with bacterial growth by inhibiting translation. Here we show that Api137, a derivative of the insect-produced antimicrobial peptide apidaecin, arrests terminating ribosomes using a unique mechanism of action… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 67 references

Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons

  • P Huter
  • Nature
  • 2016

Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome

  • AC Seefeldt
  • Nucleic Acids Res
  • 2016

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