An antimetastatic role for decorin in breast cancer.

  title={An antimetastatic role for decorin in breast cancer.},
  author={Silvia Goldoni and Daniela G. Seidler and Jack Heath and Matteo Fassan and Raffaele Baffa and Mathew L. Thakur and Rick T. Owens and David James McQuillan and Renato V Iozzo},
  journal={The American journal of pathology},
  volume={173 3},
Decorin, a member of the small leucine-rich proteoglycan gene family, down-regulates members of the ErbB receptor tyrosine kinase family and attenuates their signaling, leading to growth inhibition. We investigated the effects of decorin on the growth of ErbB2-overexpressing mammary carcinoma cells in comparison with AG879, an established ErbB2 kinase inhibitor. Cell proliferation and anchorage-independent growth assays showed that decorin was a potent inhibitor of breast cancer cell growth and… CONTINUE READING