An antigen-specific signal is required for the activation of second- order suppressor T cells in the regulation of delayed-type hypersensitivity to 2,4,6-trinitrobenzene sulfonic acid

@article{Tsurufuji1983AnAS,
  title={An antigen-specific signal is required for the activation of second- order suppressor T cells in the regulation of delayed-type hypersensitivity to 2,4,6-trinitrobenzene sulfonic acid},
  author={Makoto Tsurufuji and Baruj Benacerraf and Man Sun Sy},
  journal={The Journal of Experimental Medicine},
  year={1983},
  volume={158},
  pages={932 - 945}
}
Suppressor T cells (Ts-1) induced with trinitrophenyl (TNP)-conjugated syngeneic spleen cells (TNP-SC) can be enriched on antigen-coated plates and are afferent suppressors. In addition, these suppressor cells produced soluble suppressor factors (TsF) that were active in vivo. Therefore, the Ts-1 cells in the TNP system are very similar to the Ts-1 cells in other systems we have studied earlier. Further characterization of these TsF-1 revealed that TsF-1 obtained from TNP-SC-induced Ts-1 is… CONTINUE READING

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Suppressor T cell circuits.

Annals of the New York Academy of Sciences • 1982

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