An antigen-specific semi-therapeutic treatment with local delivery of tolerogenic factors through a dual-sized microparticle system blocks experimental autoimmune encephalomyelitis.

@article{Cho2017AnAS,
  title={An antigen-specific semi-therapeutic treatment with local delivery of tolerogenic factors through a dual-sized microparticle system blocks experimental autoimmune encephalomyelitis.},
  author={Jonathan J. Cho and Joshua M Stewart and Theodore T Drashansky and Maigan A Brusko and Ashley N. Zuniga and Kyle J. Lorentsen and Benjamin G Keselowsky and Dorina Avram},
  journal={Biomaterials},
  year={2017},
  volume={143},
  pages={
          79-92
        }
}
Antigen-specific treatments are highly desirable for autoimmune diseases in contrast to treatments which induce systemic immunosuppression. A novel antigen-specific therapy has been developed which, when administered semi-therapeutically, is highly efficacious in the treatment of the mouse model for multiple sclerosis, experimental autoimmune encephalomyelitis (EAE). The treatment uses dual-sized, polymeric microparticles (dMPs) loaded with specific antigen and tolerizing factors for intra- and… CONTINUE READING
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