An antifreeze glycopeptide gene from the antarctic cod Notothenia coriiceps neglecta encodes a polyprotein of high peptide copy number.

@article{Hsiao1990AnAG,
  title={An antifreeze glycopeptide gene from the antarctic cod Notothenia coriiceps neglecta encodes a polyprotein of high peptide copy number.},
  author={Kevin Cheng-Wen Hsiao and C. C. Cheng and Irene Fernandes and H William Detrich and Arthur L. Devries},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 23},
  pages={9265-9}
}
The antarctic fish Notothenia coriiceps neglecta synthesizes eight antifreeze glycopeptides (AFGP 1-8; Mr 2600-34,000) to avoid freezing in its ice-laden freezing habitat. We report here the sequence of one of its AFGP genes. The structural gene contains 46 tandemly repeated segments, each encoding one AFGP peptide plus a 3-amino acid spacer. Most of the repeats (44/46) code for peptides of AFGP 8; the remaining 2 code for peptides of AFGP 7. At least 2 of the 3 amino acids in the spacers could… CONTINUE READING

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