An antiestrogen-binding protein in human tissues.

@article{Kon1983AnAP,
  title={An antiestrogen-binding protein in human tissues.},
  author={Oi Lian Kon},
  journal={The Journal of biological chemistry},
  year={1983},
  volume={258 5},
  pages={
          3173-7
        }
}
  • Oi Lian Kon
  • Published in The Journal of biological chemistry 1983
Although nonsteroidal antiestrogens of the triphenylethylene type are generally considered to act through the estrogen receptor, some observations suggest that estrogen target tissues may also contain a binding protein specific for these compounds. The data so far reported, however, are also consistent with ligand-induced changes in conformation or in the state of aggregation of the estrogen receptor. The studies reported here demonstrate the existence of a protein in human myometrial cytosol… CONTINUE READING

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