An antibody with high reactivity for disease-associated α-synuclein reveals extensive brain pathology

@article{Kovacs2012AnAW,
  title={An antibody with high reactivity for disease-associated α-synuclein reveals extensive brain pathology},
  author={Gabor G Kovacs and Uta Wagner and Beno{\^i}t Dumont and Maria Pikkarainen and Awad A. Osman and Nathalie Streichenberger and Irene Leisser and J{\'e}r{\'e}my Verch{\`e}re and Thierry Baron and Irina Alafuzoff and H Budka and Armand Perret-Liaudet and Ingolf Lachmann},
  journal={Acta Neuropathologica},
  year={2012},
  volume={124},
  pages={37-50}
}
α-Synuclein is the major protein associated with Lewy body dementia, Parkinson’s disease and multiple system atrophy. Since α-synuclein is present in the brain in physiological conditions as a presynaptic protein, it is crucial to characterize disease-associated modifications to develop an in vivo biomarker. With the aim to develop antibodies showing high specificity and sensitivity for disease-associated α-synuclein, synthetic peptides containing different amino acid sequences were used for… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Similar Papers

Loading similar papers…