An antibody to IP-10 is a potent antagonist of cell migration in vitro and in vivo and does not affect disease in several animal models of inflammation.

@article{Byrne2009AnAT,
  title={An antibody to IP-10 is a potent antagonist of cell migration in vitro and in vivo and does not affect disease in several animal models of inflammation.},
  author={Fergus Byrne and Aaron G Winters and David W. Brankow and Sylvia Nai-Yu Hu and Todd Juan and Shirley Steavenson and George J. Doellgast and Kamesh R Kuchimanchi and Heather Brown and Sharon Anderson and Sara C Smelt and T O'Moore Sullivan and Dina Alcorn and Joel Tocker and Charley Dean and John Macmaster and Jacqueline Kirchner and Janet Buys and Raffi Manoukian and Eric Jiao and X. Kelvin Zou and Gabriele S. V. Campanella and Gerald Siu},
  journal={Autoimmunity},
  year={2009},
  volume={42 3},
  pages={
          171-82
        }
}
IP-10 secretion is induced by pro-inflammatory cytokines and mediates the migration of CXCR3+ cells. Its elevation in clinical samples has been associated with multiple inflammatory diseases and its antagonism has been reported to be effective in several animal models of inflammatory disease. We generated a mouse anti-mouse IP-10 monoclonal antibody (mAb; Clone 20A9) that specifically bound murine IP-10 with high affinity and inhibited in vitro IP-10 induced BaF3/mCXCR3 cell migration with an… CONTINUE READING
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