An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour

@article{MotamediShad2016AnAT,
  title={An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour},
  author={Neda Motamedi-Shad and A. Jagger and M. Liedtke and Sarah V Faull and A. Nanda and E. Salvadori and J. Wort and C. Kay and N. Heyer-Chauhan and E. Miranda and Juan P{\'e}rez and A. Ord{\'o}{\~n}ez and I. Haq and J. Irving and D. Lomas},
  journal={Biochemical Journal},
  year={2016},
  volume={473},
  pages={3269 - 3290}
}
Serpins are important regulators of proteolytic pathways with an antiprotease activity that involves a conformational transition from a metastable to a hyperstable state. Certain mutations permit the transition to occur in the absence of a protease; when associated with an intermolecular interaction, this yields linear polymers of hyperstable serpin molecules, which accumulate at the site of synthesis. This is the basis of many pathologies termed the serpinopathies. We have previously… Expand
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