An antibody delivery system for regulated expression of therapeutic levels of monoclonal antibodies in vivo.

@article{Fang2007AnAD,
  title={An antibody delivery system for regulated expression of therapeutic levels of monoclonal antibodies in vivo.},
  author={Jianmin Fang and Saili Yi and Andrew D. Simmons and Guang Huan Tu and Minh Quan Nguyen and Thomas C. Harding and Melinda Vanroey and Karin Jooss},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2007},
  volume={15 6},
  pages={1153-9}
}
Monoclonal antibody (mAb) delivery by gene transfer in vivo may be an attractive alternative to current mAb therapies for applications that require long-term therapy. This article describes a transfer system that allows inducible high-level expression of unmodified mAbs in vivo. A recombinant adeno-associated viral (rAAV) vector is used that comprises an expression cassette consisting of a dimerizer-regulated promoter that drives expression of the antibody heavy and light chains linked by a 2A… CONTINUE READING

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