An antibody-cytotoxic conjugate, BIIB015, is a new targeted therapy for Cripto positive tumours.

  title={An antibody-cytotoxic conjugate, BIIB015, is a new targeted therapy for Cripto positive tumours.},
  author={R. Kelly and Dian L Olson and Y. Sun and D. Wen and Kathleen Wortham and Giovanna Antognetti and Anne E Cheung and O. Orozco and L. Yang and V. Bailly and M. Sanicola},
  journal={European journal of cancer},
  volume={47 11},
  • R. Kelly, Dian L Olson, +8 authors M. Sanicola
  • Published 2011
  • Biology, Medicine
  • European journal of cancer
  • BIIB015 is an immunoconjugate created for the treatment of solid tumours and is currently in Phase I of clinical evaluation. BIIB015 consists of a humanised monoclonal antibody against the Cripto protein carrying a payload, via a hindered disulphide linker, of the maytansinoid derivative, DM4. Cripto is a GPI-linked protein required for signal transduction of the TGF-beta ligand, Nodal. Cripto has been previously described as an oncogene and fits the classic pattern of an embryonic gene that is… CONTINUE READING
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