An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells

@article{Tang2011AnAA,
  title={An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells},
  author={Chad Tang and Andrew Stephen Lee and Jens-Peter Volkmer and Debashis Sahoo and Divya Nag and Adriane R Mosley and Matthew A Inlay and Reza Ardehali and Shawn L Chavez and Renee Reijo Pera and Barry Behr and Joseph C Wu and Irving L. Weissman and Micha Drukker},
  journal={Nature Biotechnology},
  year={2011},
  volume={29},
  pages={829-834}
}
An important risk in the clinical application of human pluripotent stem cells (hPSCs), including human embryonic and induced pluripotent stem cells (hESCs and hiPSCs), is teratoma formation by residual undifferentiated cells. We raised a monoclonal antibody against hESCs, designated anti–stage-specific embryonic antigen (SSEA)-5, which binds a previously unidentified antigen highly and specifically expressed on hPSCs—the H type-1 glycan. Separation based on SSEA-5 expression through… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

intrinsic immunogenicity of in vitro maintained and matured populations

C. Tang, Drukker, M. Potential barriers to therapeutics utilizing pluri derivatives
  • Semin. Immunopathol. published online, doi: 10.1007/s00281-011-0269-5
  • 2011

a method of mining developmentally regulated genes using Boolean implications

Sahoo, D. et al. MiDReG
  • Proc. Natl. Acad. Sci. USA 107, 5732–5737
  • 2010

Effects of cell number on teratoma formation by human embryonic stem cells

Lee, A.S
  • Cell Cycle
  • 2009

Evaluation of essential parameters for future safety studies

Hentze, H. et al. Teratoma formation by human embryonic stem cells
  • Stem Cell Res. 2, 198–210
  • 2009