An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition.

@article{Eleftherianos2007AnAP,
  title={An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition.},
  author={Ioannis Eleftherianos and Sam Boundy and Susan A. Joyce and Shazia Aslam and James W. Marshall and Russell J Cox and Thomas J Simpson and David J Clarke and Richard H. ffrench-Constant and Stuart E. Reynolds},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 7},
  pages={2419-24}
}
Photorhabdus is a virulent pathogen that kills its insect host by overcoming immune responses. The bacterium also secretes a range of antibiotics to suppress the growth of other invading microorganisms. Here we show that Photorhabdus produces a small-molecule antibiotic (E)-1,3-dihydroxy-2-(isopropyl)-5-(2-phenylethenyl)benzene (ST) that also acts as an inhibitor of phenoloxidase (PO) in the insect host Manduca sexta. The Photorhabdus gene stlA encodes an enzyme that produces cinnamic acid, a… CONTINUE READING