An antibiotic policy to prevent emergence of resistant bacilli.

@article{Man2000AnAP,
  title={An antibiotic policy to prevent emergence of resistant bacilli.},
  author={Peter de Man and Bart Verhoeven and Henri A. Verbrugh and M. van den Nieuwboer S. van Hemert E. Claassen W. M. Vos and Johannes N van den Anker},
  journal={Lancet},
  year={2000},
  volume={355 9208},
  pages={973-8}
}
BACKGROUND Fear of infection in neonatal intensive care units (NICUs) often leads to early use of empiric broad-spectrum antibiotics, a strategy that selects for resistant bacteria. We investigated whether the emergence of resistant strains could be halted by modifying the empiric antibiotic regimens to remove the selective pressure that favours resistant bacteria. METHODS Two identical NICUs were assigned to different empiric antibiotic regimens. On unit A, penicillin G and tobramycin were… CONTINUE READING
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