An anti-human CD13 monoclonal antibody that suppresses the suppressive function of Treg cells.

Abstract

CD13 (CD13/aminopeptidase N, APN, or CD13/APN) is a widely expressed type II membrane-bound metalloprotease. It is often overexpressed on cancer cells and expressed on CD4(+)CD25(hi) Treg cell subpopulation with higher suppressive ability. It has been determined to be a promising target in cancer diagnosis and therapy. In this study, a functional anti-human… (More)
DOI: 10.1089/mab.2012.0078

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@article{Zhang2013AnAC, title={An anti-human CD13 monoclonal antibody that suppresses the suppressive function of Treg cells.}, author={Kai Zhang and Wei Chen and Yun Zhang and Yan Ge and Songwen Ju and Peng Yang and Yongfei Tan and Zhijun Ge and Zhihong Cao and Yanpin Zhao and Haorong Wu and Songguang Ju}, journal={Monoclonal antibodies in immunodiagnosis and immunotherapy}, year={2013}, volume={32 1}, pages={16-20} }