An anti-B cell autoantibody from Wiskott-Aldrich syndrome which recognizes i blood group specificity on normal human B cells.

@article{GrillotCourvalin1992AnAC,
  title={An anti-B cell autoantibody from Wiskott-Aldrich syndrome which recognizes i blood group specificity on normal human B cells.},
  author={Catherine Grillot-Courvalin and Jean Claude Brouet and Friedrich Piller and Laura Z. Rassenti and Sylvaine Labaume and Gregg J Silverman and Lev Silberstein and Thomas J. Kipps},
  journal={European journal of immunology},
  year={1992},
  volume={22 7},
  pages={1781-8}
}
We previously identified IgM autoantibodies in the sera of patients with Wiskott-Aldrich syndrome (WAS) that react with a subset of normal human B lymphocytes and induce B cell differentiation in vitro. From splenocytes of a patient with WAS we generated heterohybridomas (HY18 and HY21) and a lymphoblastoid cell line (LWA10) that produce human IgM lambda or IgM kappa anti-B lymphocyte autoantibodies, respectively. Immunohistochemical and multiparameter flow cytometric analyses demonstrate that… CONTINUE READING

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