An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies

@article{Ye2010AnAM,
  title={An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies},
  author={Xiaofeng Ye and Yunfang Li and Scott S. Stawicki and S. J. De Couto and Jeff Eastham-Anderson and Dara Y Kallop and Robby M. Weimer and Yaqun Wu and Li Chun Pei},
  journal={Oncogene},
  year={2010},
  volume={29},
  pages={5254-5264}
}
Axl is expressed in various types of cancer and is involved in multiple processes of tumorigenesis, including promoting tumor cell growth, migration, invasion, metastasis as well as angiogenesis. To evaluate further the mechanisms involved in the expression/activation of Axl in various aspects of tumorigenesis, especially its roles in modulating tumor stromal functions, we have developed a phage-derived mAb (YW327.6S2) that recognizes both human and murine Axl. YW327.6S2 binds to both human and… CONTINUE READING

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