An anti‐interferon activity shared by paramyxovirus C proteins: Inhibition of Toll‐like receptor 7/9‐dependent alpha interferon induction

@article{Yamaguchi2014AnAA,
  title={An anti‐interferon activity shared by paramyxovirus C proteins: Inhibition of Toll‐like receptor 7/9‐dependent alpha interferon induction},
  author={Mayu Yamaguchi and Yoshinori Kitagawa and Min Zhou and Masae Itoh and Bin Gotoh},
  journal={FEBS Letters},
  year={2014},
  volume={588}
}
Paramyxovirus C protein targets the host interferon (IFN) system for virus immune evasion. To identify its unknown anti‐IFN activity, we examined the effect of Sendai virus C protein on activation of the IFN‐α promoter via various signaling pathways. This study uncovers a novel ability of C protein to block Toll‐like receptor (TLR) 7‐ and TLR9‐dependent IFN‐α induction, which is specific to plasmacytoid dendritic cells. C protein interacts with a serine/threonine kinase IKKα and inhibits… 
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