An anthrax lethal factor-neutralizing monoclonal antibody protects rats before and after challenge with anthrax toxin.

@article{Lim2005AnAL,
  title={An anthrax lethal factor-neutralizing monoclonal antibody protects rats before and after challenge with anthrax toxin.},
  author={Nam-Kyu Lim and Jung-Hwan Kim and Mee Sook Oh and Sangyoon Lee and Se-Yeon Kim and Keun-Soo Kim and H. Kang and Hyo Jeong Hong and Kyung-Soo Inn},
  journal={Infection and immunity},
  year={2005},
  volume={73 10},
  pages={
          6547-51
        }
}
Lethal factor (LF) is a component of anthrax lethal toxin (LeTx). We generated anti-LF murine monoclonal antibodies (MAbs) that show LeTx-neutralizing activity in vitro and in vivo. Anti-LF MAbs were generated by immunization with recombinant LF, and the MAbs showing LeTx-neutralizing activity in vitro were selected. Two MAbs with the highest affinities, 5B13B1 (dissociation constant [K(d)], 2.62 nM) and 3C16C3 (K(d), 8.18 nM), were shown to recognize the same or closely overlapping epitopes on… CONTINUE READING
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