An anthelmintic compound, nafuredin, shows selective inhibition of complex I in helminth mitochondria.

@article{Omura2001AnAC,
  title={An anthelmintic compound, nafuredin, shows selective inhibition of complex I in helminth mitochondria.},
  author={Satoshi O̅mura and Hiroko Miyadera and Hideaki Ui and Kazuro Shiomi and Yuichi Yamaguchi and Rokuro Masuma and Tohru Nagamitsu and Daisuke Takano and Toshiaki Sunazuka and Achim Harder and Heinz Koelbl and Michio Namikoshi and Hideto Miyoshi and Kazuhito Sakamoto and Kiyoshi Kita},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 1},
  pages={60-2}
}
Infections with parasitic helminths are important causes of morbidity and mortality worldwide. New drugs that are parasite specific and minimally toxic to the host are needed to counter these infections effectively. Here we report the finding of a previously unidentified compound, nafuredin, from Aspergillus niger. Nafuredin inhibits NADH-fumarate reductase (complexes I + II) activity, a unique anaerobic electron transport system in helminth mitochondria, at nM order. It competes for the… CONTINUE READING

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Infections with parasitic helminths are important causes of morbidity and mortality worldwide .
Infections with parasitic helminths are important causes of morbidity and mortality worldwide .
Infections with parasitic helminths are important causes of morbidity and mortality worldwide .
Infections with parasitic helminths are important causes of morbidity and mortality worldwide .
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