An antagonistic interaction between A2B adenosine and D2 dopamine receptors modulates the function of rat carotid body chemoreceptor cells.

@article{Conde2008AnAI,
  title={An antagonistic interaction between A2B adenosine and D2 dopamine receptors modulates the function of rat carotid body chemoreceptor cells.},
  author={S{\'i}lvia V Conde and Constancio Gonz{\'a}lez and Joana Rita Batuca and Em{\'i}lia Carreira Monteiro and Ana Obeso},
  journal={Journal of neurochemistry},
  year={2008},
  volume={107 5},
  pages={1369-81}
}
We have previously demonstrated that adenosine controls the release of catecholamines (CA) from carotid body (CB) acting on A2B receptors. Here, we have tested the hypothesis that the control is exerted via an interaction between adenosine A2B and dopamine D2 receptors present in chemoreceptor cells. Experiments were performed in vitro in CB from 3 months rats. The effect of A2B adenosine and D2 dopamine agonists and antagonists applied alone or in combination were studied on basal (20%O2) and… CONTINUE READING
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